MODEL-INFORMED EXPERIMENTAL DESIGN RECOMMENDATIONS FOR DISTINGUISHING INTRINSIC AND ACQUIRED TARGETED THERAPEUTIC RESISTANCE IN HEAD AND NECK CANCER

Model-informed experimental design recommendations for distinguishing intrinsic and acquired targeted therapeutic resistance in head and neck cancer

Abstract The promise of precision medicine has been limited by the pervasive resistance to many targeted therapies for cancer.Inferring the timing (i.e., pre-existing or acquired) and mechanism (i.e., drug-induced) of such resistance Color Changing Mug is crucial for designing effective new therapeutics.This paper studies cetuximab resistance in he

read more

Comparative Analysis of Clinical Factors Associated with Ocular Surface Squamous Neoplasia in HIV Infected and Non HIV Patients

Introduction: Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial disease ranging from dysplasia to invasive Moisturiser carcinoma.HIV infection is an important risk factor postulated for the development of disease.Aim: To compare and to find out any statistically significant difference in patient de

read more

Environmental and nutritional requirements for tea cultivation

Tea (Camellia sinensis) is an important beverage crop cultivated in the tropics and subtropics under acid soil conditions.Increased awareness of the health-promoting properties of the tea beverage Body has led to an increase in its level of consumption over the last decades.Tea production contributes significantly to the economy of several tea-cult

read more