Model-informed experimental design recommendations for distinguishing intrinsic and acquired targeted therapeutic resistance in head and neck cancer
Abstract The promise of precision medicine has been limited by the pervasive resistance to many targeted therapies for cancer.Inferring the timing (i.e., pre-existing or acquired) and mechanism (i.e., drug-induced) of such resistance Color Changing Mug is crucial for designing effective new therapeutics.This paper studies cetuximab resistance in he